| 2026 | Campeón Gabacho | Actor |
| 2026 | Los Lobos: Native Sons | Self |
| 2025 | Alexander and the Terrible, Horrible, No Good, Very Bad Road Trip | Gil Morales |
| 2024 | The Long Game | Pollo |
| 2023 | Champions | Julio |
| 2022 | To Be Blunt | Self |
| 2022 | Shotgun Wedding | Robert Rivera |
| 2021 | Luis Jimenez Documentary | Self |
| 2020 | The War with Grandpa | Danny |
| 2019 | Siqueiros: Walls of Passion | David Alfaro Siqueiros |
| 2019 | Carlos Almaraz: Playing with Fire | Self |
| 2019 | Inmate #1: The Rise of Danny Trejo | Self |
| 2017 | Coco | Corrections Officer (voice) |
| 2017 | Cars 3 | Ramone (voice) |
| 2016 | Americano | Martin |
| 2016 | Dark Harvest | Ricardo |
| 2016 | Good Fortune | Self |
| 2014 | The Radiator Springs 500½ | Ramone (voice) |
| 2014 | The Book of Life | Pancho Rodriguez (voice) |
| 2013 | Cheech & Chong's Animated Movie | Writer |
| 2013 | Cheech & Chong's Animated Movie | Self |
| 2012 | The Wild Adventures of El Santos | El Narrador |
| 2012 | The Wild Adventures of El Santos | El Charro Negro |
| 2011 | Cars 2 | Ramone (voice) |
| 2011 | Hoodwinked Too! Hood VS. Evil | Mad Hog (voice) |
| 2010 | Pure Country 2: The Gift | Pedro |
| 2010 | Machete | Padre Cortez |
| 2010 | Hey Watch This | Self |
| 2010 | Hey Watch This | Various |
| 2010 | Hey Watch This | Writer |
| 2009 | The Perfect Game | Padre Esteban |
| 2009 | Race to Witch Mountain | Eddie |
| 2008 | Beverly Hills Chihuahua | Manuel (voice) |
| 2008 | Roadside Romeo | Chhainu |
| 2007 | Uncle P | Juan |
| 2007 | Grindhouse | Padre (segment "Planet Terror") |
| 2007 | Planet Terror | Priest |
| 2006 | Lalo Guerrero: The Original Chicano | Actor |
| 2006 | Cars | Ramone (voice) |
| 2006 | Mater and the Ghostlight | Ramone (voice) |
| 2005 | Underclassman | Captain Victor Delgado |
| 2004 | The Lion King 1½ | Banzai (voice) |
| 2004 | Christmas with the Kranks | Officer Salino |
| 2003 | This So-Called Disaster | Esteban |
| 2003 | Once Upon a Time in Mexico | Belini |
| 2003 | Spy Kids 3-D: Game Over | Felix Gumm |
| 2003 | Hollywood High | Self |
| 2003 | The Leo and the Friends | Hugo the Hyena |
| 2002 | Spy Kids 2: The Island of Lost Dreams | Felix Gumm |
| 2002 | The Original Latin Kings of Comedy | Self |
| 2002 | The Original Latin Kings of Comedy | Writer |
| 2001 | Spy Kids | Felix Gumm |
| 2000 | Picking Up the Pieces | Mayor Machado |
| 1999 | Luminarias | Jesus |
| 1998 | Paulie | Ignacio |
| 1996 | The Great White Hype | Julio Escobar |
| 1996 | From Dusk Till Dawn | Border Guard / Chet Pussy / Carlos |
| 1996 | Tin Cup | Romeo Posar |
| 1995 | Desperado | Short Bartender |
| 1994 | The Lion King | Banzai (voice) |
| 1994 | The Magic of the Golden Bear: Goldy III | Master Borgia |
| 1992 | FernGully: The Last Rainforest | Stump (voice) |
| 1992 | Ring of the Musketeers | Burt Aramis |
| 1990 | The Shrimp on the Barbie | Carlos |
| 1989 | Ghostbusters II | Dock Supervisor |
| 1989 | Rude Awakening | Jesús Monteya |
| 1988 | Oliver & Company | Tito (voice) |
| 1988 | Goldy 3: The Search for the Golden Bear | Actor |
| 1988 | The Art of Disney Animation | Self |
| 1987 | Born in East L.A. | Rudy |
| 1987 | Born in East L.A. | written by |
| 1987 | Born in East L.A. | Director |
| 1985 | Get Out of My Room | Ian Rotten |
| 1985 | Get Out of My Room | Cheech |
| 1985 | Echo Park | Syd |
| 1985 | Get Out of My Room | Writer |
| 1985 | Get Out of My Room | Director |
| 1985 | After Hours | Neil |
| 1984 | Cheech & Chong's: The Corsican Brothers | Louis Corsican |
| 1984 | Cannonball Run II | Tire Store Employee (uncredited) |
| 1984 | Cheech & Chong's: The Corsican Brothers | written by |
| 1983 | Return Engagement | Self |
| 1983 | Still Smokin | Cheech |
| 1983 | Still Smokin | Writer |
| 1983 | Yellowbeard | El Segundo |
| 1982 | Things Are Tough All Over | written by |
| 1982 | It Came from Hollywood | Self |
| 1981 | Nice Dreams | written by |
| 1981 | Nice Dreams | Cheech |
| 1980 | Cheech and Chong's Next Movie | Cheech |
| 1980 | Cheech and Chong's Next Movie | Dwayne 'Red' Mendoza |
| 1980 | Cheech and Chong's Next Movie | written by |
| 1978 | Up in Smoke | Pedro |
| 1978 | Up in Smoke | Writer |